Other Endocrine Abnormalities

Rarely, adrenal enlargement, and excessive secretion of the adrenal hormone cortisol is seen in McCune-Albright syndrome. This may cause obesity of the face and trunk, weight gain, skin fragility and cessation of growth in childhood. These symptoms are called Cushing's Syndrome. Treatment is removal of the affected adrenal glands, or use of drugs which block cortisol synthesis.

Some children with McCune-Albright syndrome have very low levels of phosphorus in the blood due to excessive losses of phosphate in the urine. This may cause bone weakening and the condition called rickets. It may be treated with oral phosphates and supplemental vitamin D.
 

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