Thyroid Function

Almost 50% of patients with McCune-Albright syndrome have thyroid gland abnormalities; these include generalized enlargement called goiter, and irregular masses such as nodules and cysts. Some patients have subtle structural changes detected only by ultrasonography. Pituitary thyroid-stimulating-hormone (TSH) levels are low in these patients, and thyroid hormone levels may be normal or elevated. Therapy with drugs which block thyroid hormone synthesis (Propylthiouracil or Methimazole), can be given if thyroid hormone levels are excessively high.


 

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